Wayne State | Department of Surgery (313) 745-8778

Selected Publications

PEER REVIEWED PUBLICATIONS (2010-2013)

  1. Batchu RB, Gruzdyn O, Weaver DW, Gruber SA. MAGE-A3 With Cell-Penetrating Domain as an Efficient Therapeutic Cancer Vaccine. JAMA surgery 03/2014; DOI:10.1001/jamasurg.2013.4113.
  2. Ramesh B. Batchu, Oksana V Gruzdyn, Christopher S Bryant, Aamer M Qazi, Sanjeev Kumar, Sreedhar Chamala, Shu T Kung, Ramana S Sanka, Udaya S Puttagunta, Donald W Weaver, Scott Gruber. Ritonavir-Mediated Induction of Apoptosis Occurs via RB/E2F-1 and AKT Pathways in Pancreatic Cancer. Pharmaceuticals 2014, 7, 46-57.
  3. Ramesh B. Batchu, Oksana V Gruzdyn, Shu T Kung, Donald W Weaver, Scott Gruber. Dendritic cell based immunotherapy of cancer with cell penetrating domains.. Indian J Surg Oncol. 2014, 5, 3-4.
  4. Ramesh B. Batchu, Oksana Gruzdyn, Shu T. Kung, Scott A. Gruber. Dendritic cell based immunotherapy of cancer with cell penetrating domains. Indian J Surg Oncol, DOI 10.1007/s13193-013-0277-01.2013, 2014
  5. Batchu RB, Gruzdyn OV, Moreno-bost AM, et al. Efficient lysis of epithelial ovarian cancer cells by MAGE-A3-induced cytotoxic T lymphocytes using rAAV-6 capsid mutant vector. Vaccine. 2014 Jan 6. pii: S0264-410X(13)01792-1. doi: 10.1016/j.vaccine.2013.12.049.
  6. RB Batchu PhD, AM Qazi PhD, OV Gruzdyn BS, A Semaan MD, S Seward MD, S Chamala MD, VB Dhulipala MD, DL Bouwman MD, DW Weaver MD, & SA Gruber MD, PhD, MBA. EZH2-shRNA Mediated Up-regulation of p21waf1/cip1 and its Transcriptional Enhancers with Concomitant Down-modulation of Mutant p53 in Pancreatic Ductal Adenocarcinoma. 2013. Surgery, In Press.
  7. Seward S, Semaan A, Qazi AM, Gruzdyn OV, Chamala S, Bryant CC, Kumar S, Cameron D, Sethi S, Ali-Fehmi R, Morris R, Bouwman DL, Munkarah AR, Weaver DW, Gruber SA, Batchu RB. EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21waf1/cip1 and by inhibiting mutant p53. Cancer Lett. 336: 53-60. PMID: 23603558. 2013.
  8. Aamer M Qazi, Oksana Gruzdyn, Assaad Semaan, Shelly Seward, Sreedhar Chamala, Vasu Dhulipala, Seema Sethi, Rouba Ali‐Fehmi, Philip A Philip, David L Bouwman, Donald W Weaver, Scott A Gruber, Ramesh B Batchu. Restoration of E-Cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101. Surgery 152: 704-11. PMID: 22943841.  2012.
  9. Mahdi, Haider; Kumar, Sanjeev; Seward, Shelly; Semaan, Assaad; Batchu, Ramesh; Lockhart, David; Tamimi, Hisham; Munkarah, Adnan R. Prognostic Impact of Laterality in Malignant Ovarian Germ Cell Tumors. Int J Gynecol Cancer, 21: 257-262. PMID: 21475076. 2011.
  10. Pal J, Bertheau R, Buon L, Qazi A, Batchu RB, Bandopadhyay S, Ali-Fehmi R, Beer DG, Weaver DW, Reis RS, Goyal RK, Huang Q, Munshi NC, Shammas MA. Genomic evolution in Barrett’s adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome. Oncogene, 30: 3585-98. PMID: 21423218. 2011.
  11. Assaad Semaan, Aamer M. Qazi, Shelly Seward, Sreedhar Chamala, Vasu B. Dhulipala, Seema Sethi, Rouba Ali-Fehmi, Robert Morris, Christopher P. Steffes, David L. Bouwman, Adnan R Munkarah, Donald W. Weaver, Scott A. Gruber & Ramesh B. Batchu. miR-101 inhibits growth of ovarian cancer xenografts by relieving chromatin-mediated transcriptional repression of p21waf1/cip1.Pharmaceutical Res, 28: 3079-90. PMID: 21818714.  2011.
  12. Christopher S. Bryant, M.D., Sanjeev Kumar, M.D., Aamer Qazi, Ph.D., Robert T. Morris, M.D., Christopher P Steffes, M.D., Madhu Prasad, M.D., Donald Weaver, M.D., Masood Shammas, Ph.D., & Ramesh B. Batchu, Ph.D. Sulforaphane Induces Cell Cycle Arrest by Protecting RB-E2F-1 Complex in Epithelial Ovarian Cancer Cells. Mol Cancer, 9:47. PMID: 20196847. 2010.
  13. Bryant CS, Munkarah AR, Kumar S, Batchu RB, Shah JP, Morris RT, Jiang ZL Saed GM. Reduction of hypoxia-induced angiogenesis in ovarian cancer cells by inhibition of HIF-1alpha gene expression. Arch Gynecol Obstet, 282:677-83. PMID: 20140681. 2010.
  14. Qazi A, Pal J, Maitah M, Fulciniti M, Pelluru D, Nanjappa P, Lee S, Batchu RB, Prasad M, Bryant CS, Rajput S, Gryaznov S, Beer DG, Weaver DW, Munshi NC, Goyal RK, Shammas MA. Anticancer activity of a broccoli derivative, sulforaphane, in barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy. Transl Oncol. 3: 389-99. PMID: 21151478. 2010.

 

BOOK AUTHORSHIPS, EDITORSHIPS, AND CHAPTERS

  1. Laser capture microdissection of pancreatic ductal adeno-carcinoma cells to analyze EzH2 by Western Blot analysis. Aamer M Qazi; Sita Aggarwal; Christopher S Steffer; David L Bouwman; Donald W Weaver; Scott A Gruber; Ramesh B Batchu.  Methods Mol Biol, 755:245-56. PMID: 21761309. 2011.
  2. Crippling of HIV at Multiple Stages with Recombinant Adeno-Associated Viral Mediated RNA Interference. Oksana V. Gruzdyn, Aamer M. Qazi1, Assaad Y. Semaan, Shelly M. Seward, Christopher P. Steffes, David L. Bouwman, Donald W. Weaver and Scott A. Gruber. Recent Translational Research in HIV/AIDS. Edited by Prof. Yi-Wei Tang.. Publisher InTech. ISBN 978-953-307-719-2. 2011.
  3. Genomic Medicine Today. David Ellis and Ramesh Babu Batchu. Hospital & Health Networks Daily RSSj. October, 2011.

 

NON PEER REVIEWED PUBLICATIONS (2009-2013)

  1. Impact of Sulforaphane, alone or in combination with paclitaxel, on cell growth, genome-wide expression profile, and genomic integrity in Barrett’s adeno-carcinoma cells. A. Qazi, K. B. Stark, R. B. Batchu, S. Chamala, C. S. Bryant, C. P. Steffes, D. G. Beer, D. W. Weaver, M. Prasad, M. A. Shammas.  J Surg Res, 151: 252, 2009
  2. Impact of Sulforaphane, Alone or in Combination with Paclitaxel, on Cell Growth, Genome-Wide Expression Profile, and Genomic Integrity, in Barrett’s Adenocarcinoma Cells. A. Qazi, K.B. Stark, R.B. Batchu, S. Chamala, C.S. Bryant, C.P. Steffes, D.G. Beer, D.W. Weaver, M. Prasad, M.A. Shammas.  J Surg Res, Vol. 151, Issue 2, Page 252, 2009
  3. Expression of Mir-101 Inhibits Cell Growth and Proliferation by Down Regulation of EZH2 in PANC-1 Cells Both In Vitro and In Vivo. Ramesh B. Batchu, Aamer Qazi, Assaad Semaan, Sreedhar Chamala, Shelly Seward, Christopher P. Steffes, Masood A. Shammas, Donald W. Weaver. Gastroenterology. Volume 138, Issue 5, Supplement 1, Pages S-548-S-549, 2010
  4. EZH2 Knock Down by Lentiviral shRNA Inhibits Pancreatic Ductal Adeno-Carcinoma Cell Proliferation In Vitro and Tumor Growth In Vivo. Ramesh B. Batchu, Aamer Qazi, Shelly Seward, Masood A. Shammas, Sreedhar Chamala, Assaad Semaan, Christopher P. Steffes, Donald W. Weaver.   Gastroenterology. Volume 138, Issue 5, Supplement 1, Pages S-548, 2010
  5. Anticancer Activity of a Broccoli Derivative, Sulforaphane, in Barrett’s Adenocarcinoma: Potential use in Chemoprevention and as Adjuvant in Chemotherapy. Aamer Qazi, Jagannath Pal, Ma’in Maitah, Mariateresa Fulciniti, Dheeraj Pelluru, Puru Nanjappa, Ramesh B. Batchu, Madhu Prasad, Christopher S. Bryant, Samiyah Rajput, Saem Lee, Kenneth C. Anderson, Sergei Gryaznov, David G. Beer, Donald W. Weaver, Nikhil C. Munshi, Raj K. Goyal, Masood A. Shammas.  Gastroenterology Vol. 138, Issue 5, Supplement 1, Page S-500. 2010
  6. Role of Recombinase (RAD51) in Ongoing Genomic Instability and Proliferation in Barrett’s Adenocarcinoma Cells. Jagannath Pal, Robert C. Bertheau, Leutz Buon, Aamer Qazi, Ramesh B. Batchu, Rouba Ali-Fehmi, Saem Lee, David G. Beer, Donald W. Weaver, Nikhil C. Munshi, Raj K. Goyal, Masood A. Shammas.  Gastroenterology Vol. 138, Issue 5, Supplement 1, Page S-505. 2010
  7. PI 3-Kinase Inhibitor (Wortmannin) Inhibits DNA Recombination, Genomic Instability, and Growth of Barrett’s Adenocarcinoma Cells. Jagannath Pal, Mariateresa Fulciniti, Leutz Buon, Aamer Qazi, Samir B. Amin, Ramesh B. Batchu, Saem Lee, David G. Beer, Kenneth C. Anderson, Donald W. Weaver, Nikhil C. Munshi, Raj K. Goyal, Masood A. Shammas.  Gastroenterology Vol. 138, Issue 5, Supplement 1, Pages S-499-S-500, 2010
  8. Relationship of miR-101 and targeted epigenetic silencing of EzH2 on cell growth and invasiveness in ovarian cancer cells. R. B. Batchu, A. Semaan, S. M. Seward, A. Qazi, S. Chamala, C. S. Bryant, C. Steffes, S. Kumar, M. A. Shammas, D. W. Weaver.  J Clin Oncol 28 (suppl; abstr e15538) 2010
  9. B Cell Transduction of Capsid Mutant (Y730F) Adeno-Associated Virus-2 Vectors with Mage-A3 Gene for Immunotherapy of Colorectal Cancer. R.B. Batchu, A.M. Qazi, S. Seward, M. Haider, K. Khalil, A. Semaan, C. Steffes, P. Madhu, D.W. Weaver.   J Surg Res, Vol. 158, Issue 2, Page 197, 2010
  10. Epigenetic Silencing of EzH2 By RNA Interference As A Potential Therapy For Pancreatic Adenocarcinoma. R.B. Batchu, A.M. Qazi, A.Y. Semaan, S.M. Seward, S. Chamala, V.B. Dhulipala, C. David, C.S. Bryant, S. Kumar, C. Steffes, P. Philip, D. Bouwman, D.W. Weaver.   J Surg Res, Vol. 165, Issue 2, Page 178, 2011
  11. MicroRNA-101 (miR-101) Enhances Chemosensitivity of Pancreatic Ductal Adenocarcinoma (PDAC) Cells By Inhibition of MTOR Signaling Via PRAS40. R.B. Batchu, O. Gruzdyn, A.M. Qazi, D. Bouwman, S.A. Gruber, D.W. Weaver.  J Surg Res, Vol. 172, Issue 2, Page 233, 2012
  12. MicroRNA-101 (miR-101) Promotes Expression of E-cadherin (E-Cad) By Relieving Epigenetic Repression in Epithelial Ovarian Cancer (EOC). R.B. Batchu, O. Gruzdyn, A.M. Qazi, A. Semaan, D. Bouwman, D.W. Weaver, S.A. Gruber.  J Surg Res, Vol. 172, Issue 2, Pages 313-314, 2012
  13. Negative Regulation of Mutant P53 by MicroRNA-101 (miR-101) in Pancreatic Ductal Adenocarcinoma (PDAC). R.B. Batchu, O. Gruzdyn, A. Qazi, S.T. Kung, D.W. Weaver and S.A. Gruber. Journal of Surg Res, Vol. 179, Issue 2 , Page 341, 2013

 

INVITED LECTURES (2012-2013)

  1. Enhancer of Zeste Homolog 2 (EZH2) Silencing Down-modulates Mutant p53 with Increased Chemosensitivity in Epithelial Ovarian Cancer (EOC). Ramesh B. Batchu PhD, Oksana Gruzdyn BS, Aamer M. Qazi PhD, Shelly Seward MD, Donald W. Weaver, MD, Scott A. Gruber, MD, PhD, MBA. American College of Surgeons (ACS) Clinical Congress, Washington, DC, October 7th, 2013.
  2. Enhanced dendritic cell permeability of genetically engineered MAGE-A3 with cell penetrating domain (CPD) for the generation of an efficient therapeutic cancer vaccine. Batchu RB, Gruzdyn O, Kung ST, BS, Weaver D, Gruber SA. Association of VA Surgeons (AVAS), Milwaukee, WI , April, 21-23, 2013.
  3. EZH2-shRNA mediated up-regulation of p21WAF1/CIP1 and its transcriptional enhancers with concomitant down-modulation of mutant p53 in pancreatic ductal adeno-carcinoma (PDAC). RB Batchu, OV Gruzdyn, AM Qazi, DW Weaver, SA Gruber. Central Surgical Association (CSA) Omni Amelia Island Plantation – Amelia Island, FL, March 14-16, 2013.|
  4. Negative Regulation Of Mutant P53 By MicroRNA-101 (miR-101) In Pancreatic Ductal Adenocarcinoma (PDAC). R. B. Batchu, O. Gruzdyn, A. Qazi, S.T. King, D.W. Weaver, S.A. Gruber. ASC20130348. 8th Annual Academic Surgical Congress (ASC), New Orleans, LA, February 5-7, 2013.
  5. R. B. Batchu, Inhibition of mammalian target of rapamycin (MTOR) signaling by microrna-101 (mir-101) results in enhanced chemosensitivity of epithelial ovarian cancer (EOC) cells. Association of VA surgeons, 36th Annual Meeting, April 1-3, 2012.
  6. R. B. Batchu, Restoration Of E-Cadherin (E-Cad) Expression In Pancreatic Ductal Adenocarcinoma (PDAC) Treated With MicroRNA-101 (MiR-101). Central Surgical Association, Annual Meeting. March 1-3, Madison, Wisconsin, 2012.
  7. Ramesh B. Batchu, Oksana Gruzdyn, Donald. W. Weaver and Scott A. Gruber. Novel Tyrosine Mutant Recombinant Adeno-associated Viral (rAAV) Transduction of Dendritic Cells (DCs) as a Step Towards Therapeutic Vaccination in Multiple Myeloma (MM) ACS 98th Annual Clinical Congress, Sep 30 – Oct 4, Chicago, IL, 2012.
  8. R. B. Batchu, MicroRNA-101 (miR-101) Enhances Chemosensitivity Of Pancreatic Ductal Adenocarcinoma (PDAC) Cells By Inhibition Of MTOR Signaling Via PRAS40. 7th Annual Academic Surgical Congress – February 14-16, Las Vegas, Nevada, 2012.
  9. R. B. Batchu, MicroRNA-101 (miR-101) Promotes Expression Of E-cadherin (E-Cad) By Relieving Epigenetic Repression In Epithelial Ovarian Cancer (EOC), 7th Annual Academic Surgical Congress – February 14-16, Las Vegas, Nevada, 2012.
  10. R. B. Batchu, A. M. Qazi, A. Y. Semaan, S. M. Seward, S. Chamala, V. B. Dhulipala, C. David, C. S. Bryant, S. Kumar, C. Steffes, P. Philip, D. Bouwman, D. W. Weaver. “Epigenetic Silencing Of EzH2 By RNA Interference As A Potential Therapy For Pancreatic Adenocarcinoma” Sixth Annual Academic Surgical Congress, Session; Oncology – Oncology Basic Science: Cell Signaling & Apoptosis. Huntington Beach, CA, Feb 01, 2011.
  11. R. B. Batchu, A. M. Qazi, S. Seward, M. Haider, K. Khalil, A. Semaan, C. Steffes, P. Madhu, D. W. Weaver. B Cell Transduction Of Capsid Mutant (Y730F) Adeno-Associated Virus-2 Vectors With Mage-A3 Gene For Immunotherapy Of Colorectal Cancer. Session: Oncology 3: Targeted Therapy/Immunobiology and Therapy. 5th Annual Academic Surgical Congress. San Antonio, TX. February 3,2010. 
  12. R. B. Batchu, A. Qazi, K. B. Stark, S. Chamala, C. S. Bryant, C. P. Steffes, D. G. Beer, D. W. Weaver, M. Prasad, M. A. Shammas; Impact Of Sulforaphane, Alone Or In Combination With Paclitaxel, On Cell Growth, Genome-Wide Expression Profile, And Genomic Integrity, In Barrett’s Adenocarcinoma Cells.  4th Annual Academic Surgical Congress. Session:  Oncology 5, apoptosis. Fort Myers, FL, February 3-6, 2009.
  13. Ramesh B. Batchu, “Ritonavir mediated protection of retinoblastoma-E2F-1 complex at G1 phase of cell cycle in pancreatic cancer cell lines” ACS 94th Annual Clinical Congress: (SF23) Surgical Oncology, San Francisco, CA, October 12-16, 2008.