Wayne State | Department of Surgery (313) 745-8778

Selected Publications


  1. Speyer, C.L., Hachem, A.H., Assi, A.A., Johnson, J.S., DeVries, J.A., and Gorski, D.H. Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer. PLOS ONE (submitted)
  2. Banda, M., Speyer, C.L., Semma, S.N., Kingsley, O., Kim, H.J., Kounalaskis, N., Torres, K.E., Barnard, N.J., Sloane, B.F., Miller, F.R., Goydos, J.S., and Gorski, D.H. Metabotropic glutamate receptor-1 signaling is oncogenic in triple negative breast cancer. PLOS ONE (submitted)
  3. Speyer, C.L., Smith, J.S., Banda, M., Mekani, T., Gorski, D.H. Metabotropic Glutamate receptor-1: A potential therapeutic target in triple negative breast cancer. Breast Cancer Res Treat, 132, 565-573, 2012.
  4. Speyer, C.L. and Ward, P.A. Role of Endothelial Chemokines and their Receptors during Inflammation. J Invest Surg, 24(1), 18-27, 2011.
  5. Chen, Y., Banda, M., Speyer, C.L., Smith, J.S., Rabson, A., and Gorski, D.H. Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221. Mol Cell Biol, 20(15), 3902-13, 2010.
  6. Gao, H., Neff, TA, Guo, R., Speyer, CL, Sarma, JV, Tomlins, S, Man, Y, Riedemann, NC, Hoesel, LM, Younkin, E, Zetoune, FS, and Ward, PA. Evidence for a functional role of the second C5a receptor C5L2. FASEB J, 19(8), 1003-5, 2005
  7. Neff, T.A., Guo, R.F., Neff, S.B., Sarma, J.V., Speyer, C.L., Gao, H., Bernacki, K.D., Huber-Lang, M., McGuire, S., Hoesel, M., Riedemann, N.C., Beck-Schimmer, B., Zetoune, F.S., and Ward, P.A.  Relationship of Acute Lung Inflammatory Injury to Fas/FasL System. Am J Path, 166, 685-694, 2005
  8. Speyer, C.L., Rancilio, N.J., McClintock, S.D., *Crawford, J.D., Gao, H., Sarma, J.V., and Ward, P.A.  Regulatory effects of estrogen on  acute lung inflammation in mice. Am J Physiol Cell Physiol, 288, C881-890, 2005
  9. Speyer, C.L., Gao, H., Rancilio, N.J., Neff, T.A., Huffnagle, G.B., Sarma, J.V., and Ward, P.A. Novel chemokine responsiveness and mobilization of neutrophils during sepsis. Am J Path, 165, 1-10, 2005
  10. Warner, R.L., Winter, H.C., Speyer, C.L., Varani, J., Goldstein, I.J., Murphy, H.S., and Johnson, K.J. Marasmius oreades lectin induces renal thrombotic microangiopathic lesions. Exp. Molec. Pathol, 77, 77-84, 2004
  11. Gao, H., Guo, R., Speyer, C.L., Reuben, J., Neff, T.A., Hoesel, L.M., Riedemann, N.C., McClintock,  S.D., Sarma, J.A., Rooijen, N.V., Zetoune, F.S., and Ward, P.A. Stat3 activation in acute lung injury. J Immun, 172 (12), 7703-12, 2004
  12. Laudes, I.J., Guo, R.F., Riedemann, N.C., Speyer, C., Craig, R., Sarma, J.V., and Ward, P.A. Disturbed homeostasis of lung intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 during sepsis. Am J Pathol. 164, 1435-45, 2004
  13. Riedemann, N.C., Guo, R.F., Hollmann, T.J., Gao, H., Neff, T.A., Reuben, J.S., Speyer, C.L., Sarma, J.V., Wetsel, R.A., Zetoune, F.S., and Ward, P.A.  Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. FASEB J. 18, 370-2, 2004
  14. Speyer, C.L., Neff, T.A., Warner, R.L., Guo, R.F., Sarma, J.V., Riedemann, N.C., Murphy, M.E., Murphy, H.S. and Ward, P.A. Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol. 163, 2319-28, 2003
  15. Riedemann, N.C., Guo, R.F., Bernacki, K.D., Reuben, J.S., Laudes, I.J., Neff, T.A., Gao, H., Speyer, C.L., Sarma, V.J., Zetoune, F.S., and Ward, P.A. Regulation by C5a of neutrophil activation during sepsis. Immunity. 19, 193-202, 2003
  16. Herskovic, J.J., Speyer, C.L., Simples, J.E., Steffes, C.P. and Ram, J.L. Lipopolysaccharide (LPS) enhancement of outward current in lung pericytes. Lung 180, 215-220, 2002
  17. Laudes, I.J., Chu, J.C., Huber-Lang, M., Guo, R.F., Riedemann, N.C., Sarma, J.V., Mahdi, F., Murphy, H.S., Speyer, C., Lu, K.T., Lambris, J.D., Zetoune, F.S., and Ward, P.A. Expression and function of C5a receptor in mouse microvascular endothelial cells. J Immun. 169, 5962-5970, 2002
  18. Riedemann, N.C., Guo, R.F., Sarma, V.J., Laudes, I.J., Huber-Lang, M., Warner, R.L., Albrecht, E.A., Speyer, C.L., and Ward, P.A. Expression and function of the C5a receptor (C5aR) in rat alveolar epithelial cells. J Immun. 168, 1919-25, 2002
  19. Speyer, C.L., Steffes, C.P., Tyburski, J.G., Homan, R., and Ram, J.L. Lipopolysaccharide-induced secretory phospholipase A2 activity in pericytes: a possible mechanism for mediating relaxation. Microvasc Res. 63, 239-242, 2002
  20. Kerkar, S., Speyer C., Tyburski, J. and Steffes, C. Reactive oxygen metabolites induce a biphasic contractile response in microvascular lung pericytes. J Trauma. 51, 440-5, 2001
  21. Dente, C.J., Steffes, C.P., Speyer C.L., and Tyburski, J.G. Pericytes augment the capillary barrier in in-vitro cocultures.  J Surg Res. 97, 85-91, 2001
  22. Speyer, C.L. Regulation of LPS-induced relaxation in the rat lung pericyte. Dissertation, Wayne State University, Detroit, MI, 2000
  23. Speyer, C.L., Steffes, C.P., Tyburski, J.G., and Ram, J.L. Lipopolysaccharide induces relaxation in lung pericytes by an iNOS-independent mechanism. Am J Physiol: Lung Cell Mol Physiol. 278, L880-L887, 2000
  24. SpeyerC.L., Steffes, C.P., and Ram, J.L. Effects of  vasoactive mediators on the rat lung pericyte: quantitative analysis of contraction on collagen lattice matrices. Microvasc Res. 57, 134-143, 1999
  25. Purchase, C.L., II, White, A.D., Anderson, M.K., Bocan, T.M.A., Bousley, R.F., Hamelehle, K.L., Homan, R., Krause, B.R., Lee, P., Bak-Mueller, S., Speyer, C., Stanfield, R.L. and Reindel, J.F. Tetrazole-substituted ureas as inhibitors of acyl-CoA:cholesterol O- acyltransferase (ACAT). A novel preparation of ureas from weakly nucleophilic amines. Bioorganic Med. Chem. Lett. 6, 1753-1758, 1996
  26. Lee, H.T., Sliskovic, D.R., Picard, J.A., Roth, B.D., Wierenga, W., Hicks, J.L., Bousley, R.F., Hamelehle, K.L., Homan, R., Speyer, C., Stanfield, R.L. and Krause, B.R. Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets. J. Med. Chem. 39, 5031-5034, 1996



  • Invited speaker for the Breast Cancer Biology & Proteases and Cancer Joint Retreat Program (December 14, 2010)
  • Invited speaker for the Biological Sciences Departmental Seminar Series at University of Michigan – Flint (June 29, 2010)
  • Invited lecturer (gastrointestinal immunology) for the Department of Physiology at Wayne State University School of Medicine (April 2007 to 2008)
  • Invited speaker for the 2005 Physiology Department Graduate Student Day Program at Wayne State University School of Medicine
  • Invited presenter for the Northville Public School’s Career Day Seminar Series 2002
  • Dissertation presentation and defense in the Physiology Department at Wayne State University School of Medicine 2000