Wayne State | Department of Surgery (313) 745-8778

Ramesh Babu Batchu, M.Phil., Ph.D.

Director, Division of Surgical Oncology and Developmental Therapeutics
Associate Professor

The Michael and Marian Ilitch Department of Surgery
Wayne State University School of Medicine
John D Dingell VAMC

Position: Full-Time

Office Address:

John D Dingell VAMC
Office Room B4235
4646 John R Road, Detroit, MI 48201, USA

Email: rbatchu@med.wayne.edu
Phone: 313-576-3304
Fax: 1-313-576-3112

Laboratory: B4242, Phone: (313)576-3002
Laboratory: B4321, Phone: (313)576-3304

SPECIALTY: Immuno-gene therapy and RNA interference

PRIMARY SITE:  John D Dingell VAMC

AFFILIATIONS:  John D Dingell VAMC

RESEARCH INTERESTS:  PANCREATIC AND OVARIAN CANCERS

EDUCATION:
– M.Sc., University of Hyderabad, Hyderabad, India
– M.Phil., Ph.D., Jawaharlal Nehru University, New Delhi, India.
– Post-doctoral Fellowship: University of Arkansas, Little Rock, AR.

1. Engraftment of mesothelin chimeric antigen receptor using a hybrid Sleeping Beauty/minicircle vector into NK-92MI cells for treatment of pancreatic cancer
Ramesh B Batchu, Oksana V Gruzdyn, Pavan S Tavva, Bala K Kolli, Rajesh Dachepalli, Donald W Weaver, Scott A Gruber. Surgery 166 (4), 503-508. 2019

2. Inhibition of IL-10 Augments Mesothelin Chimeric Antigen Receptor T Cell Activity in Epithelial Ovarian Cancer
Ramesh B Batchu, Oksana V Gruzdyn, Ebrahem M Mahmud, Sagar Rohondia, Santosh K Manmari, Suman P Tavva, Udaya P Sri, Gamal Mostafa, Donald W Weaver, Scott A Gruber. Journal of the American College of Surgeons 227 (4), e215-e216. 2018

3. Inhibition of Interleukin-10 in the tumor microenvironment can restore mesothelin chimeric antigen receptor T cell activity in pancreatic cancer in vitro
Ramesh B Batchu, Oksana V Gruzdyn, Ebrahem M Mahmud, Fatme Chukr, Rajesh Dachepalli, Santosh K Manmari, Gamal Mostafa, Donald W Weaver, Scott A Gruber. Surgery 163 (3), 627-632. 2018

4. Mesothelin Chimeric Antigen Receptor (CAR)-Mediated Therapy for Ovarian Cancer
Oksana V Gruzdyn, Scott A Gruber, Ramesh B Batchu, Ebrahem M Mahmud, Fatme K Chukr, Rajesh Dachepalli, Santosh K Manmari, Advaitha Tiruvaipati, Gamal Mostafa, Donald W Weaver. Journal of the American College of Surgeons 225 (4), e47. 2017

5. Pancreatic Cancer Cell Lysis by Cell-Penetrating Peptide-MAGE-A3–Induced Cytotoxic T Lymphocytes
Ramesh B Batchu, Oksana V Gruzdyn, Aamer M Qazi, Ebrahem M Mahmud, Gamal Mostafa, Donald W Weaver, Scott A Gruber. JAMA surgery 151 (11), 1086-1088. 2016

Medical Students – Instruction in laboratory research, cell culture techniques associated with RNA interference projects.

Graduate Students – Honors thesis with immunotherapy projects, instruction in laboratory research, cell culture techniques.

Residents – Laboratory training, process of blood products, dendritic cell and T cell-related culture work.