Wayne State | Department of Surgery (313) 745-8778

Ramesh Babu Batchu, M.Phil., Ph.D.

Director, Division of Surgical Oncology and Developmental Therapeutics
Associate Professor
The Michael and Marian Ilitch Department of Surgery
Wayne State University School of Medicine
John D Dingell VAMC

Position: Full-Time

Office Address:

John D Dingell VAMC
Office Room B4235
4646 John R Road, Detroit, MI 48201, USA
Email: rbatchu@med.wayne.edu
FAX: 1-313-576-3112
Phone: 313-576-3304

Laboratory: B4242, Phone: 313-576-3002
Laboratory: B4321, Phone: 1-313-576-3304

SPECIALTY: Immuno-gene therapy and RNA interference

PRIMARY SITE:  John D Dingell VAMC

AFFILIATIONS:  John D Dingell VAMC

RESEARCH INTERESTS:  PANCREATIC AND OVARIAN CANCERS

EDUCATION:
– M.Sc., University of Hyderabad, Hyderabad, India
– M.Phil., Ph.D., Jawaharlal Nehru University, New Delhi, India.
– Post-doctoral Fellowship: University of Arkansas, Little Rock, AR.

1. Batchu RB, Gruzdyn OV, Mahmud EM, Chukr F, Dachepalli R, Manmari SK, Mostafa G, Weaver DW, Gruber SA. Inhibition of IL-10 in the tumor microenvironment can restore mesothelin chimeric antigen receptor T cell activity in pancreatic cancer in vitro. Surgery. 2018 Mar;163:627-632. PMID: 29336814.

2. Batchu RB, Gruzdyn OV, Mahmud EM, Rohondia S, Manmari SK, Tavva SP, Udaya PS, Mostafa G, Weaver DW, Gruber SA. Inhibition of IL-10 augments mesothelin chimeric antigen receptor T cell activity in epithelial ovarian cancer. J Am Coll Surg. 227(4):e215-e216. 2018.

3. Batchu RB, Gruzdyn OV, Mahmud EM, Chukr FK, Dachepalli R, Manmari SK, Tiruvaipati A, Mostafa G, Weaver DW, Gruber SA. Mesothelin Chimeric Antigen Receptor (CAR)-Mediated Therapy for Ovarian Cancer. J Am Coll Surg. 225(4): e47. 2017.

4. Batchu RB, Gruzdyn OV, Qazi AM, Mahmud EM, Mostafa G, Weaver DW, Gruber SA. Pancreatic Cancer Cell Lysis by Cell-Penetrating Peptide-MAGE-A3-Induced Cytotoxic T Lymphocytes. JAMA Surg. 2016 Nov 1; 151:1086. PMID: 27851862.

5. Batchu RB, Gruzdyn OV, Qazi AM, Kaur J, Mahmud EM, Weaver DW, Gruber SA. Enhanced phosphorylation of p53 by microRNA-26a leading to growth inhibition of pancreatic cancer. Surgery. 2015 Oct; 158:981. PMID: 26189069.

6. Batchu RB, Gruzdyn OV, Moreno-Bost AM, Szmania S, Jayandharan G, Srivastava A, Kolli BK, Weaver DW, van Rhee F, Gruber SA. Efficient lysis of epithelial ovarian cancer cells by MAGE-A3-induced cytotoxic T lymphocytes using rAAV-6 capsid mutant vector. Vaccine. 2014 Feb 12; 32:938. PMID: 24406390.

7. Batchu RB, Gruzdyn OV, Bryant CS, Qazi AM, Kumar S, Chamala S, Kung ST, Sanka RS, Puttagunta US, Weaver DW, Gruber SA. Ritonavir-Mediated Induction of Apoptosis in Pancreatic Cancer Occurs via the RB/E2F-1 and AKT Pathways. Pharmaceuticals (Basel). 2014 Jan 9; 7:46. PMID: 24451403.

8. Batchu RB, Gruzdyn O, Potti RB, Weaver DW, Gruber SA. MAGE-A3 with cell-penetrating domain as an efficient therapeutic cancer vaccine. JAMA Surg. 2014 May; 149:451. PMID: 24671426.

9. Seward S, Semaan A, Qazi AM, Gruzdyn OV, Chamala S, Bryant CC, Kumar S, Cameron D, Sethi S, Ali-Fehmi R, Morris R, Bouwman DL, Munkarah AR, Weaver DW, Gruber SA, Batchu RB. EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53. Cancer Lett. 2013 Aug 9; 336:53. PMID: 23603558.

10. Batchu RB, Qazi AM, Gruzdyn OV, Semaan A, Seward SM, Chamala S, Dhulipala VB, Bouwman DL, Weaver DW, Gruber SA. EZH2-shRNA-mediated upregulation of p21waf1/cip1 and its transcriptional enhancers with concomitant downmodulation of mutant p53 in pancreatic ductal adenocarcinoma. Surgery. 2013 Oct; 154:739.

Medical Students – Instruction in laboratory research, cell culture techniques associated with RNA interference projects.

Graduate Students – Honors thesis with immunotherapy projects, instruction in laboratory research, cell culture techniques.

Residents – Laboratory training, process of blood products, dendritic cell and T cell-related culture work.